We're harnessing the body's natural healing abilities through innovative exosome therapeutics for intervention in intractable medical conditions including neurodegenerative disorders, chronic pain and dermatological conditions. Our Kiseke platform, employing sophisticated analytics and AI, seamlessly blends the manufacturing process with disorder-specific needs, facilitating the identification of therapeutic targets and the fine-tuning of manufacturing and treatment protocols for peak effectiveness. Our goal is to forge a dynamic regenerative medicine ecosystem, uniting innovation, patient care, and data-centric approaches, setting the stage for tailored regenerative treatments.

Publications

  • Kweh MF, Parks M, Salerno AG, Vaughn, White IA., (2023) Topical Application of Purified Amniotic Fluid Accelerated Healing of Full-Thickness Burns, Negating the Need for Skin Grafts: A Case Report.Journal of Wound Management and Research. 19(1): 53-58.

    Salerno AG, Kweh MF, Hunt T, White IA.,(2022) Advances in Cardiovascular Regenerative Medicine. Epidemiology Sci. Vol 12(6).

    Gonzalez, MJ., Kweh, MF., Biava, PM., Olalde, J., Toro, AP., Goldschmidt-Clermont, PJ., White, IA. (2021) Evaluation of Exosome Derivatives as Bio-Informational Reprogramming Therapy for Cancer. Journal of Translational Medicine. Mar 9;19(1):103.

    Rajan, SS., Amin, AD., Li, L., Rolland, DC., Li, H., Kwon, D., Kweh, MF., Arumov, A., Roberts, ER., Yan, A., Basrur, V., Elenitoba-Johnson, KSJ., Chen, XS., Puvvada, SD., Lussier, YA., Bilbao, D., Lim, MS., Schatz, JH. (2020) The Mechanism of Cancer Drug Addiction in ALK-Positive T-Cell Lymphoma. Oncogene. Mar;39(10):2103-2117.

    Kweh, MF., Merriman, KE., Wells, T., Nelson, CD. (2020) Vitamin D Signaling Increases Nitric Oxide and Antioxidant Defenses of Bovine Monocytes. J Dairy Sci. Jan;103(1):805-822.

    Poindexter, MB., Kweh, MF., Zimpel, R., Zuniga, J., Lopera, C., Zenobi, MG., Jiang, Y., Engstrom, M., Celi, P., Santos, JEP., Nelson, CD. (2020) Feeding Supplemental 25-Hydroxyvitamin D3 Increases Serum Mineral Concentrations and Alters Mammary Immunity of Lactating Dairy Cows. J Dairy Sci. 2020 Jan;103(1):805-822.

    Rajan, SS., Li, L., Kweh, MF., Kunkalla, K., Amin, AD., Agarwal, NK., Vega, F., Schatz, JH. (2019) CRISPR Genome Editing of Murine Hematopoietic Stem Cells to Create Npm1-Alk Causes ALK+ Lymphoma After Transplantation. Blood Adv. Jun 25;3(12):1788-1794.

    Kweh, MF., Merriman, KE., Nelson, CD. (2019) Inhibition of DNA Methyltransferase and Histone Deacetylase Increases Β-Defensin Expression but Not the Effects of Lipopolysaccharide or 1,25-dihydroxyvitamin D3 in Bovine Mammary Epithelial Cells. J Dairy Sci. Jun;102(6):5706-5712.

    Nelson, CD., Merriman, KE., Poindexter, MB., Kweh, MF., Blakely, LP. (2018) Symposium Review: Targeting Antimicrobial Defenses of the Udder Through an Intrinsic Cellular Pathway. J Dairy Sci. Mar;101(3):2753-2761.

    Merriman, KE., Poindexter, MB., Kweh, MF., Santos, JEP., Nelson, CD. (2017) Intramammary 1,25- dihydroxyvitamin D3 Treatment Increases Expression of Host-Defense Genes in Mammary Immune Cells of Lactating Dairy Cattle. J Steroid Biochem Mol Biol. Oct;173:33-41.

    Venkatesh, P., Phillippi, J., Chukkapalli, S., Rivera-Kweh, M., Velsko, I., Gleason, T., VanRyzin, P., Aalaei-Andabili, SH., Ghanta, RK., Beaver, T., Chan, EKL., Kesavalu, L. (2017) Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms. Int J Mol Sci. Apr 20;18(4).

    Aguirre, JI., Akhter, MP., Neuville, KG., Trcalek, CR., Leeper, AM., Williams, AA., Rivera, M., Kesavalu, L., Ke, HZ., Liu, M., Kimmel, DB. (2017) Age-Related Periodontitis and Alveolar Bone Loss in Rice Rats. Arch Oral Biol. Jan;73:193-205.

    Chukkapalli, SS., Easwaran, M., Rivera-Kweh, MF., Velsko, IM., Ambadapadi, S., Dai, J., Larjava, H., Lucas, AR., Kesavalu, L. (2017) Sequential Colonization of Periodontal Pathogens in Induction of Periodontal Disease and Atherosclerosis in LDLRnull Mice. Pathog Dis. Jan 1;75(1).

    Chukkapalli, S., Rivera-Kweh, M., Gehlot, P., Velsko, I., Bhattacharyya, I., Calise, SJ., Satoh, M., Chan, EK., Holoshitz, J., Kesavalu, L. (2016) Periodontal Bacterial Colonization in Synovial Tissues Exacerbates Collagen-Induced Arthritis In B10. RIII Mice. Arthritis Res Ther. Jul 12;18(1):161.

    Chukkapalli, SS., Velsko, IM., Rivera-Kweh, M., Larjava, H., Lucas, AR., Kesavalu, L. (2017) Global Tlr2 and 4 Deficiency in Mice Impacts Bone Resorption, Inflammatory Markers and Atherosclerosis to Polymicrobial Infection. Mol Oral Microbiol. Jun;32(3):211-225.

    Turner, RT., Dube, M., Branscum, AJ., Wong, CP., Olson, DA., Zhong, X., Kweh, MF., Larkin, IV., Wronski, TJ., Rosen, CJ., Kalra, SP., Iwaniec, UT. (2015) Hypothalamic Leptin Gene Therapy Reduces Body Weight Without Accelerating Age-Related Bone Loss. Endocrinol. Dec;227(3):129-41.

    Velsko, IM., Chukkapalli, SS., Rivera-Kweh, MF., Zheng, D., Aukhil, I., Lucas, AR., Larjava, H., Kesavalu, L. (2015) Periodontal Pathogens Invade Gingiva and Aortic Adventitia and Elicit Inflammasome Activation in Αvβ6 Integrin-Deficient Mice. Infect Immun. Dec;83(12):4582-93.

    Poole, S., Singhrao, SK., Chukkapalli, S., Rivera, M., Velsko, I., Kesavalu, L., Crean, S. (2015) Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains. J Alzheimers Dis.;43(1):67-80.

    Merriman, KE., Kweh, MF., Powell, JL., Lippolis, JD., Nelson, CD. (2015) Multiple Β-Defensin Genes Are Upregulated by the Vitamin D Pathway in Cattle. J Steroid Biochem Mol Biol. Nov;154:120-9.

    Chukkapalli, SS., Velsko, IM., Rivera-Kweh, MF., Zheng, D., Lucas, AR., Kesavalu, L. (2015) Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE Null Mice. PLoS One. Nov 30;10(11):e0143291.

    Velsko, IM., Chukkapalli, SS., Rivera-Kweh, MF., Chen, H., Zheng, D., Bhattacharyya, I., Gangula, PR., Lucas, AR., Kesavalu, L. (2015) Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoE(Null) Mice. PLoS One. Jun 16;10(6):e0129795.

    Gangula, P., Ravella, K., Chukkapalli, S., Rivera, M., Srinivasan, S., Hale, A., Channon, K., Southerland, J., Kesavalu, L. (2015) Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/Nnos/NRF2-Phase II Enzyme Expression. PLoS One. Jun 25;10(6):e0129885.

    Chukkapalli, SS., Rivera-Kweh, MF., Velsko, IM., Chen, H., Zheng, D., Bhattacharyya, I., Gangula, PR., Lucas, AR, Kesavalu, L. (2015) Chronic Oral Infection with Major Periodontal Bacteria Tannerella forsythia Modulates Systemic Atherosclerosis Risk Factors and Inflammatory Markers. Pathog Dis. Apr;73(3):ftv009.

    Oktay, S., Chukkapalli, SS., Rivera-Kweh, MF., Velsko, IM., Holliday, LS., Kesavalu, L. (2015) Periodontitis in Rats Induces Systemic Oxidative Stress That is Controlled by Bone-Targeted Antiresorptives. J Periodontol. Jan;86(1):137-45.

    Velsko, IM., Rivera, MF., Chukkapalli, SS., Lee, JY., Chen, H., Bhattacharyya, I., Gangula, P., Lucas, AR., Kesavalu, L. (2014) Active Invasion of Oral and Aortic Tissues by Porphyromonas gingivalis in Mice Causally Links Periodontitis and Atherosclerosis. PLoS One. May 16;9(5):e97811.

    Lucas, AR., Verma, RK., Dai, E., Liu, L., Chen, H., Kesavalu, S., Rivera, M., Velsko, I., Ambadapadi, S., Chukkapalli, S., Kesavalu, L. (2014) Myxomavirus Anti-Inflammatory Chemokine Binding Protein Reduces the Increased Plaque Growth Induced by Chronic Porphyromonas gingivalis Oral Infection After Balloon Angioplasty Aortic Injury in Mice. PLoS One. Oct 29;9(10):e111353.

    Rivera, MF., Chukkapalli, SS., Velsko, IM., Lee, JY., Bhattacharyya, I., Dolce, C., Toro, EJ., Holliday, LS., Kesavalu, L. (2014) Bis-Enoxacin Blocks Rat Alveolar Bone Resorption from Experimental Periodontitis. PLoS One. Mar 17;9(3):e92119.

    Chukkapalli, SS., Rivera, MF., Velsko, IM., Lee, JY., Chen, H., Zheng, D., Bhattacharyya, I., Gangula, PR., Lucas, AR., Kesavalu, L. (2014) Invasion of Oral and Aortic Tissues by Oral Spirochete Treponema denticola in ApoE-/- Mice Causally Links Periodontal Disease and Atherosclerosis. Infect Immun. May;82(5):1959-67.

    Rivera. MF., Lee, JY., Aneja, M., Goswami, V., Liu, L., Velsko, IM., Chukkapalli, SS., Bhattacharyya, I., Chen, H., Lucas, AR., Kesavalu, LN. (2013) Polymicrobial Infection with Major Periodontal Pathogens Induced Periodontal Disease and Aortic Atherosclerosis in Hyperlipidemic ApoE(Null) Mice. PLoS One.; 8(2):e57178.

    Toro, EJ., Zuo, J., Gutierrez, A., La Rosa, RL., Gawron, AJ., Bradaschia-Correa, V., Arana-Chavez, V., Dolce, C., Rivera, MF., Kesavalu, L., Bhattacharyya, I., Neubert, JK., Holliday, LS. (2013) Bis-Enoxacin Inhibits Bone Resorption and Orthodontic Tooth Movement. J Dent Res. Oct;92(10):925-31.

    Nahid, MA., River, M., Lucas, A., Chan, E., Kesavalu, L. (2011) Polymicrobial Infection with Periodontal Pathogens Specifically Enhances Mir-146a in ApoEnull Mice During Experimental Periodontal Disease. Infect. Immun. Apr;79(4):1597-605.

    Bainbridge, B., Verma, RK., Eastman, C., Yehia, B., Rivera, M., Moffatt, C., Bhattacharyya, I., Lamont, RJ., Kesavalu, L. (2010) Role of Porphyromonas gingivalis Phosphoserine Phosphatase Enzyme Serb in Inflammation, Immune Response and Induction of Alveolar Bone Resorption in Rats. Infect. Immun. Nov;78(11):4560-9.

    Phillips, JA., Almeida, EA., Hill, EL., Aguirre, JI., Rivera, MF., Nachbandi, I., Wronski, TJ., van der Meulen MC., Globus, RK. (2008) Role for Β1 Integrins in Cortical Osteocytes During Acute Musculoskeletal Disuse. Matrix Biol. Sep;27(7):609-18.

    Abranches, J., Nascimento, MM., Zeng, L., Browngardt, CM., Wen, ZT., Rivera, MF., Burne, RA. (2008) Ccpa Regulates Central Metabolism and Virulence Gene Expression in Streptococcus mutans. J Bacteriol. Apr;190(7):2340-9.

    Aguirre, I., Leal, ME., Rivera, MF., Vanegas, SM., Jorgensen, M., Wronski, TJ. (2007) Effects of Basic Fibroblast Growth Factor and a Prostaglandin E2 Receptor Subtype 4 Agonist on Osteoblastogenesis and Adipogenesis in Aged Ovariectomized Rats. J Bone Miner Res. Jun;22(6):877-88.

    Iwaniec, UT., Wronski, TJ., Liu, J., Rivera, MF., Arzaga, R., Rice, DS., Brommage, GB. (2007) Parathyroid Hormone Stimulates Bone Formation in Mice Deficient in Lrp5. J Bone Miner Res. Mar;22(3):394-402.

    Iwaniec, UT., Moore, K., Rivera, MF., Myers, SE., Vanegas, SM., Wronski, TJ. (2007) A Comparative Study of the Bone-Restorative Efficacy of Anabolic Agents in Aged Ovariectomized Rats. Osteoporos Int. Mar;18(3):351-62.

  • Kweh, FA, Sulsona, CR, Miller, JL, Driscoll, DJ. Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader-Willi syndrome. Obes Sci Pract. 2023; 1- 12. https://doi.org/10.1002/osp4.663

    Kweh FA, Miller JL, Sulsona CR, Wasserfall C, Atkinson M, Shuster JJ, Goldstone AP, Driscoll DJ. Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia. Am J Med Genet A. 2015 Jan;167A(1):69-79. doi: 10.1002/ajmg.a.36810. Epub 2014 Oct 29. PMID: 25355237; PMCID: PMC4391201.

    Li H, Zhang X, Fishbein L, Kweh F, Campbell-Thompson M, Perrin GQ, Muir D, Wallace M. Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells. Cancer Biol Ther. 2010 Oct 15;10(8):758-64. doi: 10.4161/cbt.10.8.12878. Epub 2010 Oct 15. PMID: 20699653; PMCID: PMC3093914.

    Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG. Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Mol Carcinog. 2009 Nov;48(11):1005-17. doi: 10.1002/mc.20552. PMID: 19479903; PMCID: PMC2783617.

    Golubovskaya VM, Kweh FA, Cance WG. Focal adhesion kinase and cancer. Histol Histopathol. 2009 Apr;24(4):503-10. doi: 10.14670/HH-24.503. PMID: 19224453.

    Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D, Cance WG. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem. 2008 Dec 11;51(23):7405-16. doi: 10.1021/jm800483v. PMID: 18989950; PMCID: PMC2662449.

    Golubovskaya VM, Finch R, Kweh F, Massoll NA, Campbell-Thompson M, Wallace MR, Cance WG. p53 regulates FAK expression in human tumor cells. Mol Carcinog. 2008 May; 47(5):373-82. doi: 10.1002/mc.20395. PMID: 17999388; PMCID: PMC4562219.

  • Munguba GC, Galeb S, Liu Y, Landy DC, Lam D, Camp AS, Samad S, Tapia ML, Lee RK. Nerve ciber layer thinning lags retinal ganglion cell density following crush axonopathy. Invest Ophthalmol Vis Sci. 2014 Sep 16. pii: IOVS-14-14525. PMID: 25228542

    Aljohani A, Munguba GC, Guerra Y, Lee RK, Bhattacharya SK. Sphingolipids and Ceramides of Human Aqueous Humor. Mol Vis. 2013 Sep 19;19:1966-84. PMID: 24068864

    Munguba GC, Geisert EE, Williams RW, Tapia ML, Lam DK, Bhattacharya SK, Lee RK. Effects of Glaucoma on Chrna6 Expression in the Retina. Curr Eye Res. 2012 Sep 24 Epub ahead of print. PMID: 23002780

    Camp AS, Ruggeri M, Munguba GC, Tapia ML, John SW, Bhattacharya SK, Lee RK. Structural correlation between the nerve ciber layer and retinal ganglion cell loss in mice with targeted disruption of the Brn3b gene. Invest Ophthalmol Vis Sci. 2011 Jul 13;52(8):5226-32. PMID: 21622702

    Munguba GC, Camp AS, Risco M, Tapia ML, Bhattacharya SK, Lee RK. Vesicular glutamate transporter 3 in age-dependent optic neuropathy. Mol Vis. 2011 Feb 5;17:413-9. PMID: 21311743

    Joo JH, Taxter TJ, Munguba GC, Kim YH, Dhaduvai K, Dunn NW, Degan WJ, Oh SP, Sugrue SP. Pinin modulates expression of an intestinal homebox gene, Cdx2, and plays an essential role for small intestinal morphogenesis. Dev Biol. 2010 Sep 15;345(2):191-203. PMID: 20637749

    Alpatov R, Shi Y, Munguba GC, Moghimi B, Joo JH, Bungert J, Sugrue SP. Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E- cadherin gene. Mol Cell Biol. 2008 Mar;28(5):1584-95. PMID: 18086895

    Joo JH, Lee YJ, Munguba GC, Park S, Taxter TJ, Elsagga MY, Jackson MR, Oh SP, Sugrue SP. Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Dev Dyn. 2007 Aug;236(8):2147-58. PMID: 17654715

    Joo JH, Alpatov R, Munguba GC, Jackson MR, Hunt ME, Sugrue SP. Reduction of Pnn by RNAi induces loss of cell-cell adhesion between human corneal epithelial cells. Mol Vis. 2005 Feb 18;11:133-42. PMID: 15735603

    Alpatov R, Munguba GC, Caton P, Joo JH, Shi Y, Shi Y, Hunt ME, Sugrue SP. Nuclear speckle- associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP- mediated repression of the E-cadherin gene. Mol Cell Biol. 2004 Dec;24(23):10223-35. PMID: 15542832

    Zimowska G, Shi J, Munguba G, Jackson MR, Alpatov R, Simmons MN, Shi Y, Sugrue SP. Pinin/ DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4715-23. PMID: 14578391

  • Shalaby, M and Sanoja AJ. Posterior Tibial Nerve Block for the Treatment of Plantar Fasciitis in the Emergency Department. Journal of Emergency Medicine. Accepted April 2023.

    Sanoja AJ, Apicella M, Perez J, Vejdani R. Deltoid Compartment Syndrome Following Posterior Glenohumeral Joint Dislocation. British Medical Journal. Submitted February 2023.

    Sanoja AJ, Shalaby M. Using POCUS to differentiate between Rectus Abdominis muscle strain from abdominal emergencies in the amateur athlete. Clinical Journal of Sports Medicine. Submitted September 2023.

    Sanoja AJ, Galindo M, Hoyme G, Laukiatis CM. Multicentric Carpotarsal Osteolysis Syndrome and Concomitant Seizure Disorder Discovered by Whole Genome Sequence Analysis, a Case Report and Review of the Literature. Journal of Medical Genetics. April 2021.

    Martinez KL, Saboda K, Mauss C, Jesudas R, Huynh JM, Sanoja AJ, Byers PH, Laukaitis CM. Patient-Reported Symptoms Do Not Differ Between People Who Do and Do Not Meet hypermobile Ehlers Danlos Syndrome (hEDS) Criteria. American Journal of Human Genetics. Accepted February 2021.

    Sanoja AJ et al. Patients affected by hEDS and G-HSD both report significant kinesiophobia and chronic pain by Tampa Scale for Kinesiophobia (TSK) assessment. Abstract. Published. American College of Medical Genetics annual meeting. April 2019.

    Sanoja AJ, Li H, Fricker FJ, Kingsmore SF, Wallace MR. Exome sequencing identifies FLNC and ADD3 variants in a family with cardiomyopathy. Journal of Translational Genetics and Genomics. 2018;2:6. https://doi.org/10.20517/jtgg.2017.13

    Laukaitis CM. Sanoja AJ, Mauss C et al. Candidate genes for hEDS: the initial results of the hEDS gene study. Abstract. Published. International Symposium on the Ehlers-Danlos Syndromes meeting. July 2018.

    Sanoja AJ, Terry H, Max V, Daniel R. Nesting pads primes the innate immune response in a pneumonia model. Abstract. Published. Harvard’s New England Science Symposium. April 2016.